Namour F, Morali A, Ilardo C, Abballe X, Maury F, Guéant J L
Laboratoire de Biochimie des Protéines, Centre Hospitalier Universitaire de Nancy-Brabois, Vandoeuvre, France.
J Pediatr Gastroenterol Nutr. 1999 May;28(5):534-7. doi: 10.1097/00005176-199905000-00019.
alpha-Glutathione S-transferase (alphaGST) has been proposed as a more sensitive indicator than serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in detecting hepatocellular damage due to chronic hepatitis C virus (HCV) infection.
The accuracy of alpha-GST was compared with that of ALT and AST in detecting cytolysis in 103 blood samples issued from 31 children positive for HCV RNA.
alpha-GST had a lower sensitivity than ALT or AST (32% vs. 54.4% for each aminotransferase). The sensitivity of ALT and/or AST was 60.2%, whereas that of ALT and/or alpha-GST and AST and/or alpha-GST was lower (58.3% and 57.3%, respectively). Among 41 serum samples with negative ALT and AST, only 2 had positive alpha-GST, whereas alpha-GST failed to detect cytolysis in 31 samples with elevated ALT and/or AST. No correlation was found between alpha-GST, ALT, or AST and the Knodell score.
The combination of ALT with AST is actually the best compromise in detecting cytolysis in untreated HCV-infected patients.
有人提出，α-谷胱甘肽S-转移酶（αGST）在检测慢性丙型肝炎病毒（HCV）感染所致肝细胞损伤方面，是比血清丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）更敏感的指标。
比较了αGST与ALT和AST在检测31例HCV RNA阳性儿童的103份血样中细胞溶解情况时的准确性。
αGST的敏感性低于ALT或AST（分别为32%和54.4%）。ALT和/或AST的敏感性为60.2%，而ALT和/或αGST以及AST和/或αGST的敏感性较低（分别为58.3%和57.3%）。在41份ALT和AST为阴性的血清样本中，只有2份αGST为阳性，而在31份ALT和/或AST升高的样本中，αGST未能检测到细胞溶解。未发现αGST、ALT或AST与Knodell评分之间存在相关性。
在检测未经治疗的HCV感染患者的细胞溶解情况时，ALT与AST的联合实际上是最佳折中方案。
