Lauer J E, Heger J J, Mirro M J
Midwest Medical Research Foundation, Fort Wayne Center for Medical Education, IN 46805, USA.
Chest. 1995 Dec;108(6):1520-3. doi: 10.1378/chest.108.6.1520.
Thrombolytic therapy salvages ischemic myocardium by rapidly reestablishing coronary artery patency in acute myocardial infarction. One of its major limitations is the complication of hemorrhage. A retrospective study of myocardial infarction patients who received thrombolytic therapy was performed to determine risk factors associated with a hemorrhagic event. Three hundred fifty patients were enrolled, and 20 (5.7%) had a bleeding complication, including four patients (1.1%) who had an intracranial hemorrhage. The factors associated with an increased risk for a significant hemorrhagic event were age (> 65 years) and female gender. Factors associated with an intracranial hemorrhage were age (> 65 years) and a history of hypertension.
溶栓疗法通过在急性心肌梗死中迅速恢复冠状动脉通畅来挽救缺血心肌。其主要局限性之一是出血并发症。对接受溶栓治疗的心肌梗死患者进行了一项回顾性研究，以确定与出血事件相关的危险因素。共纳入350例患者，其中20例（5.7%）出现出血并发症，包括4例（1.1%）发生颅内出血。与严重出血事件风险增加相关的因素是年龄（>65岁）和女性性别。与颅内出血相关的因素是年龄（>65岁）和高血压病史。
