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Study of antibody dependent cellular cytotoxicity (ADCC). III. Preliminary findings concerning the influence of immunosuppressive drugs.

作者信息

Wasik M, Rancewicz Z, Morzycka M, Juskowa J, Orłowski T

出版信息

Arch Immunol Ther Exp (Warsz). 1978;26(1-6):315-8.

PMID:749782
Abstract

The present studies were undertaken to characterize cytotoxic activity of lymphocyte-(ADCC) in the course of primary glomerulonephritis and to evaluate the influence of some of the immunosuppressive drugs on lymphocytes of examined patients. 18 patients were studied; 12 of them were treated by combined therapy with prednisone, azathioprine and chlorambucil. Results were analyzed on the basis of healthy individuals ADCC activity. In the 11 treated patients significant decrease of ADCC activity was observed while non-treated group exhibited as high activity as healthy individuals. Which of given drugs is responsible for the decreased ADCC activity, remains questionable and is currently under the study.

摘要

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引用本文的文献

1
Lymphocyte function in patients with chronic glomerulonephritis. Tests of suppressive activity generation by concanavalin A and antibody-dependent cellular cytotoxicity.慢性肾小球肾炎患者的淋巴细胞功能。伴刀豆球蛋白A诱导的抑制活性及抗体依赖性细胞毒性试验。
Int Urol Nephrol. 1983;15(1):83-92. doi: 10.1007/BF02082111.