Láng I, Fekete B, Kenéz B, Nagy Z K, Gergely P
Acta Med Acad Sci Hung. 1977;34(4):247-50.
Antibody-dependent cellular cytotoxicity by peripheral blood mononuclear cells was evaluated in 25 patients with chronic glomerulonephritis before and after combined vinblastine-cyclophosphamide-6-mercaptopurine-prednisolone therapy. Purified peripheral blood mononuclear cells of the patients mediated normal killed activity before the treatment and a strong suppression of their cytotoxic capacity was observed after the therapy. The possible significance of the inhibitory effect of immunosuppressive cytostatic treatment on human antibody-dependent cellular cytotoxicity is discussed.
在25例慢性肾小球肾炎患者中，评估了长春碱-环磷酰胺-6-巯基嘌呤-泼尼松龙联合治疗前后外周血单个核细胞的抗体依赖性细胞毒性。患者纯化的外周血单个核细胞在治疗前介导正常的杀伤活性，治疗后观察到其细胞毒性能力受到强烈抑制。文中讨论了免疫抑制性细胞毒性治疗对人抗体依赖性细胞毒性的抑制作用的可能意义。
