Kuntz C, Manner M
Chirurgische Universitätsklinik Heidelberg.
Dtsch Med Wochenschr. 1995 Dec 8;120(49):1699-702. doi: 10.1055/s-2008-1055531.
A 65-year-old woman was hospitalized with suspected cholelithiasis. The only contributory item in the history was jaundice of uncertain cause 15 years previously. Physical examination elicited pain in the right upper abdomen on deep palpation.
Alkaline phosphatase and gamma-GT activities were raised (324 and 407 U/ml, respectively). Ultrasound revealed cholecystolithiasis; the bile duct was 5 mm in diameter. Intravenous contrast-medium cholangiography showed choledocholithiasis and circular flat calcification in the bifurcation of the hepatic duct. Computed tomography revealed this structure to be a space-occupying mass (10 x 6 x 5 cm), with a calcified border (density of 27 Hounsfield units), raising the suspicion of a blood-containing hydatid cyst. Additionally there were two calculi in the left hepatic duct. But the echinococcus test (by indirect haemagglutination and enzyme-linked immunosorbent assay) was negative.
Endoscopic retrograde cholangiography (ERC) with papillotomy was performed and two choledochal concrements removed. Concrements within the mass were also visualized. Obstructive jaundice developed 3 days after the ERC and a laparotomy was performed. Excision of the hydatid was not possible because the stone-filled hydatid cavity could not be punctured. Choledochal exploration discovered membranes which histologically were chitin-like structures and corresponded to scolices. Under chemical litholysis the hydatid became smaller. In addition, albendazole was given in two four-week cycles (400 mg twice daily). The patient quickly recovered and 5 months later was symptom-free.
一名65岁女性因疑似胆石症入院。病史中唯一相关的情况是15年前曾出现过病因不明的黄疸。体格检查发现右上腹深触诊时有疼痛。
碱性磷酸酶和γ-谷氨酰转肽酶活性升高(分别为324和407 U/ml)。超声显示胆囊结石;胆管直径为5毫米。静脉造影胆管造影显示胆总管结石以及肝管分叉处的圆形扁平钙化。计算机断层扫描显示该结构为占位性肿块(10×6×5厘米),边界钙化(亨氏单位密度为27),怀疑是含血的包虫囊肿。此外,左肝管有两颗结石。但棘球蚴检查(间接血凝试验和酶联免疫吸附测定)为阴性。
进行了内镜逆行胆管造影(ERC)并切开乳头,取出了两颗胆总管结石。还观察到肿块内的结石。ERC术后3天出现梗阻性黄疸,遂进行剖腹手术。由于充满结石的包虫囊肿无法穿刺,无法切除包虫。胆总管探查发现有膜,组织学检查为几丁质样结构,与头节相符。在化学溶石治疗下,包虫变小。此外,给予阿苯达唑两个四周疗程(每日两次,每次400毫克)。患者很快康复,5个月后无症状。