Tchórzewski H, Sułowska Z, Soszyńska W
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):449-53.
The proteins isolated from human PMNL lysosome granules have activated the lymphocytes in vitro. It was found that T cells undergo transformation in response to lysosome mitogens but no LIF production was observed. Transformation induced by PHA, PWM and Con A was depressed in the presence of lysosome mitogens. The in vivo response to T-dependent antigens is amplified by lysosome mitogens. The above experiments demonstrate that lysosome mitogens stimulate T lymphocytes.
从人中性粒细胞溶酶体颗粒中分离出的蛋白质在体外激活了淋巴细胞。研究发现，T细胞会因溶酶体促细胞分裂剂而发生转化，但未观察到白细胞抑制因子的产生。在溶酶体促细胞分裂剂存在的情况下，由植物血凝素（PHA）、美洲商陆有丝分裂原（PWM）和刀豆球蛋白A（Con A）诱导的转化受到抑制。溶酶体促细胞分裂剂可增强体内对T细胞依赖性抗原的反应。上述实验表明，溶酶体促细胞分裂剂可刺激T淋巴细胞。
