Scragg R, Khaw K T, Murphy S
Clinical Gerontology Unit, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, UK.
Eur J Clin Nutr. 1995 Sep;49(9):640-6.
A possible role for vitamin D deficiency in contributing to the winter increase in cardiovascular disease mortality was investigated by testing the effect of vitamin D supplementation on blood pressure and other cardiovascular risk factors during winter.
Randomised double-blind trial of vitamin D supplementation in winter.
Men and women, mean age 70 years (range 63-76) recruited from general practitioner age-sex registers in Cambridge (UK).
95 people received a single oral dose of 2.5 mg cholecalciferol and 94 received the placebo at baseline interviews during December 1991. Follow-up assessment was 5 weeks later during January 1992.
Comparing follow-up with baseline assessment, serum 25-hydroxyvitamin D increased in the treated group and decreased slightly in the placebo group [mean (s.d.) change: 7.2 (+/- 3.8) vs -1.4 (+/- 1.1) ng/ml, P = 0.0001]; while parathyroid hormone decreased in the treated, and increased in the placebo, group [-0.27 (+/- 0.78) vs 0.13 (+/- 0.75) pmol/l, P = 0.0004]. However, the mean change in blood pressure was similar in both groups: systolic -5 (+/- 13) vs -5 (+/- 16) mmHg, P = 0.81; diastolic -1 (+/- 9) vs -1 (+/- 9), P = 0.92; as was the mean change in serum cholesterol [-0.07 (+/- 0.52) vs -0.05 (+/- 0.60) mmol/l, P = 0.81]. In contrast, the mean change in radial pulse was significantly decreased in the treated group compared with placebo [-2 (+/- 9) vs 1 (+/- 7) beats per min, P = 0.030].
The failure of vitamin D supplementation to change blood pressure or serum cholesterol suggests that the winter increase in these factors is not caused by decreased vitamin D levels.
通过测试冬季补充维生素D对血压及其他心血管危险因素的影响，研究维生素D缺乏在导致冬季心血管疾病死亡率上升方面可能发挥的作用。
冬季补充维生素D的随机双盲试验。
从英国剑桥全科医生年龄-性别登记册招募的男性和女性，平均年龄70岁（范围63 - 76岁）。
1991年12月在基线访谈时，95人接受单次口服2.5毫克胆钙化醇，94人接受安慰剂。1992年1月进行5周后的随访评估。
与基线评估相比，治疗组血清25 - 羟基维生素D升高，安慰剂组略有下降[平均（标准差）变化：7.2（±3.8）对 -1.4（±1.1）纳克/毫升，P = 0.0001]；治疗组甲状旁腺激素下降，安慰剂组上升[-0.27（±0.78）对0.13（±0.75）皮摩尔/升，P = 0.0004]。然而，两组血压的平均变化相似：收缩压 -5（±13）对 -5（±16）毫米汞柱，P = 0.81；舒张压 -1（±9）对 -1（±9），P = 0.92；血清胆固醇的平均变化也是如此[-0.07（±0.52）对 -0.05（±0.60）毫摩尔/升，P = 0.81]。相比之下，与安慰剂组相比，治疗组桡动脉脉搏的平均变化显著降低[-2（±9）对1（±7）次/分钟，P = 0.030]。
补充维生素D未能改变血压或血清胆固醇，表明冬季这些因素的增加并非由维生素D水平降低所致。
