Research Department, Clinical Affairs Directorate, Primary Health Care Corporation, Doha, Qatar
Research Department, Clinical Affairs Directorate, Primary Health Care Corporation, Doha, Qatar.
BMJ Open. 2019 Aug 18;9(8):e029334. doi: 10.1136/bmjopen-2019-029334.
To investigate the prevalence of vitamin D deficiency among individuals attending primary healthcare facilities in Qatar and to assess the association between vitamin D deficiency and some medical conditions in persons aged 18-65 years old.
The study was undertaken in publicly funded primary healthcare services in the State of Qatar.
A total of 102 342 participants aged between 18 and 65 years old with a valid serum vitamin D test result during the year 2017.
Serum level <10 ng/mL (<25 nmol/L) was defined as severe vitamin D deficiency, a serum level of <20 ng/mL (<50 nmol/L) was defined as vitamin D deficiency and a serum level <30 ng/mL (<75 nmol/L) defined as vitamin D insufficiency.
The prevalence rate of severe vitamin D deficiency was 14.1% among study participants with no history of vitamin D replacement therapy in the previous months. The prevalence rate of vitamin D deficiency was as high as 71.4% and that of vitamin D insufficiency was up to 92.7%. None of the five chronic conditions explored in the study (diabetes, hypertension, asthma, stroke and cardiovascular disease) had an obvious association with severe vitamin D deficiency status in a bivariate analysis. However, multivariate modelling showed that (adjusting for age, gender, body mass index and nationality and each of the included chronic conditions) hypertension, cardiovascular diseases and stroke placed an individual at a higher risk of having an associated severe vitamin D deficiency status.
Although not comprehensive and nationally representative, this study is suggestive of a higher prevalence of vitamin D deficiency among young adults, females, Qatari nationality and those with higher body mass index. Multivariate modelling showed that hypertension, cardiovascular diseases and stroke were associated with a higher risk of severe vitamin D deficiency status.
调查在卡塔尔的基层医疗保健机构就诊的个体中维生素 D 缺乏的流行情况,并评估 18-65 岁人群中维生素 D 缺乏与某些疾病之间的关联。
该研究在卡塔尔的公立基层医疗保健服务中进行。
共有 102342 名年龄在 18-65 岁之间的参与者,他们在 2017 年期间有有效的血清维生素 D 检测结果。
在没有在过去几个月中接受维生素 D 替代治疗的情况下,研究参与者的严重维生素 D 缺乏患病率为 14.1%。维生素 D 缺乏的患病率高达 71.4%,维生素 D 不足的患病率高达 92.7%。在单变量分析中,五种慢性疾病(糖尿病、高血压、哮喘、中风和心血管疾病)中没有一种与严重维生素 D 缺乏状态有明显关联。然而,多变量模型显示(调整年龄、性别、体重指数和国籍以及包括的五种慢性疾病中的每一种)高血压、心血管疾病和中风使个体发生相关的严重维生素 D 缺乏状态的风险更高。
尽管本研究不是全面的且不具有全国代表性,但它表明年轻成年人、女性、卡塔尔国民和体重指数较高的人群中维生素 D 缺乏的患病率较高。多变量模型显示高血压、心血管疾病和中风与严重维生素 D 缺乏状态的风险增加相关。