Pure North S'Energy Foundation, Calgary, AB T2R 0C5, Canada.
College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada.
Nutrients. 2017 Nov 14;9(11):1244. doi: 10.3390/nu9111244.
Vitamin D deficiency is a risk factor for hypertension.
We assessed 8155 participants in a community-based program to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) status and blood pressure (BP) and the influence of vitamin D supplementation on hypertension. Participants were provided vitamin D supplements to reach a target serum 25(OH)D > 100 nmol/L. A nested case-control study was conducted to examine the effect of achieving physiological vitamin D status in those who were hypertensive and not taking BP-lowering medication, and hypertensive participants that initiated BP-lowering medication after program entry.
At baseline, 592 participants (7.3%) were hypertensive; of those, 71% were no longer hypertensive at follow-up (12 ± 3 months later). There was a significant negative association between BP and serum 25(OH)D level (systolic BP: coefficient = -0.07, < 0.001; diastolic BP: coefficient = -0.1, < 0.001). Reduced mean systolic (-18 vs. -14 mmHg) and diastolic (-12 vs. -12 mmHg) BP, pulse pressure (-5 vs. -1 mmHg) and mean arterial pressure (-14 vs. -13 mmHg) were not significantly different between hypertensive participants who did and did not take BP-lowering medication.
Improved serum 25(OH)D concentrations in hypertensive individuals who were vitamin D insufficient were associated with improved control of systolic and diastolic BP.
维生素 D 缺乏是高血压的一个风险因素。
我们评估了一个社区为基础的项目中的 8155 名参与者，以调查血清 25-羟维生素 D（25（OH）D）状态与血压（BP）之间的关系，以及维生素 D 补充对高血压的影响。为了达到血清 25（OH）D > 100 nmol/L 的目标，为参与者提供了维生素 D 补充剂。进行了一项嵌套病例对照研究，以检查在未服用降压药物的高血压患者和在项目开始后开始服用降压药物的高血压患者中，实现生理维生素 D 状态的效果。
基线时，592 名参与者（7.3%）患有高血压；其中，71%在随访时（12 ± 3 个月后）不再患有高血压。BP 和血清 25（OH）D 水平之间存在显著的负相关（收缩压：系数=-0.07，<0.001；舒张压：系数=-0.1，<0.001）。收缩压（-18 对-14 mmHg）和舒张压（-12 对-12 mmHg）、脉压（-5 对-1 mmHg）和平均动脉压（-14 对-13 mmHg）的平均降低在服用和未服用降压药物的高血压参与者之间没有显著差异。
在维生素 D 不足的高血压患者中，改善血清 25（OH）D 浓度与收缩压和舒张压控制的改善相关。
