Humoral and cellular immune reaction in Balb/c mice infected with Yersinia enterocolitica.

Experiments were carried out on Balb/c mice infected with Y. enterocolitica serotypes IA, IB, II, III, IV, V and VI (according to Knopp and Thal) to check humoral and cellular immune response both primary and secondary. It was shown that the occurrence of anti-OH agglutinins and their dynamics depends on the serological type of Y. enterocolitica used for infection, and that it is related to the primary and secondary challenge. The presence of anti-OH agglutinins and hemagglutinins was observed only in cases of secondary infection of the mice. Delayed hypersensitivity evaluated as a cellular reaction assayed with a capillary test of spleen macrophages migration was found only in the cases of infection with serotypes IB, II, IV and VI. The inhibition of macrophage migration was not observed in the cases when infection of Balb/c mice had been evoked with Y. enterocolitica serotypes IA, III and V.