Ring J, Duswald K H, Bachmann T, Stephan W, Brendel W
Arch Dermatol Res (1975). 1977 Dec 27;260(3):201-6. doi: 10.1007/BF00561414.
Chemical modification of standard gammaglobulin with enzyme treatment (pepsin) or stabilization (beta-propiolactone) is able to influence elimination, fragmentation and organ distribution of intravenously administered gammaglobulins as shown in 36 dogs after i.v. application of allogenic and xenogenic gammaglobulin preparations. Pepsin-gammaglobulin was eliminated and fragmented most rapidly. Gammaglobulin concentrations of all preparations in the skin showed as slower decrease than comparable blood concentrations. The highest skin concentrations 10 days after i.v. application were found for beta-propiolactone gammaglobulin with 6.2 +/- 1.6 microgram/g compared to a blood level of 7.9 +/- 0.9 microgram/ml.
用酶处理（胃蛋白酶）或稳定化处理（β-丙内酯）对标准丙种球蛋白进行化学修饰，能够影响静脉注射丙种球蛋白的清除、片段化及器官分布，这在36只犬静脉注射同种异体和异种丙种球蛋白制剂后得到了证实。胃蛋白酶处理的丙种球蛋白清除和片段化速度最快。所有制剂在皮肤中的丙种球蛋白浓度下降速度比血液中相应浓度慢。静脉注射10天后，β-丙内酯处理的丙种球蛋白在皮肤中的浓度最高，为6.2±1.6微克/克，而血液水平为7.9±0.9微克/毫升。
