小鼠和大鼠的反应素致敏作用。

Reaginic sensitization of mice and rats.

作者信息

Wyczółkowska J, Brzezińska-Błaszczyk E, Kubicka M, Maśliński C

出版信息

Arch Immunol Ther Exp (Warsz). 1978;26(1-6):681-7.

Abstract

The reagin response to hemocyanin (KLH) and egg albumin (EA) was studied in inbred strains (Balb/c, 129, C3H/A, C57BL/6J) and Swiss-Copacabana mice. Both antigens induced apparent and in certain experimental conditions, persistent reagin production, KLH being more effective. Al(OH)3 gel as an adjuvant was more suitable for IgE antibody production, while the Freund's complete adjuvant appeared more appropriate for IgG1 antibody response. The reaginic response to EA and Al(OH)3 in rats Wistar, Sprague-Dawley and F1 hybrids (Wistar x August) was weak and transient. The best sensitization, though relatively low as compared with mouse sensitization, was obtained in Sprague-Dawley and F1 hybrids. The results suggest, that a mouse model of sensitization is quite suitable for studying the persistent reagin response, while a rat model may be useful for investigating the early suppression of reagin response.

摘要

在近交系小鼠（Balb/c、129、C3H/A、C57BL/6J）和瑞士 - 科帕卡巴纳小鼠中研究了对血蓝蛋白（KLH）和卵清蛋白（EA）的反应素反应。两种抗原均诱导出明显的，并且在某些实验条件下持续的反应素产生，其中KLH更有效。氢氧化铝凝胶作为佐剂更适合IgE抗体产生，而弗氏完全佐剂似乎更适合IgG1抗体反应。Wistar、Sprague - Dawley大鼠及F1杂种（Wistar×August）对EA和氢氧化铝的反应素反应较弱且短暂。在Sprague - Dawley大鼠和F1杂种中获得了最佳致敏效果，尽管与小鼠致敏相比相对较低。结果表明，致敏小鼠模型非常适合研究持续性反应素反应，而大鼠模型可能有助于研究反应素反应的早期抑制。