Wyczółkowska J, Michoń T, Brzezińska-Błaszczyk E, Maśliński C
Arch Immunol Ther Exp (Warsz). 1982;30(1-2):17-23.
The mice from inbred strains BALB/c, 129, C3H/A, C57BL/6J and outbred Wistar rats were tested for their capacity for reaginic sensitization on the response to antigenic stimuli. The total serum IgE level measured before immunization was highest in 129 mice and increased (2.5-3-fold) after immunization. BALB/c mice also showed an increase of the total serum IgE after immunization, whereas in two other strains such effect was not observed. All mouse strains tested produced IgE antibodies after immunization and the results suggest, that these IgE antibodies form only minor part of the total IgE content during immunization; in 129 and BALB/c mice beside IgE antibody response the production of non-specific IgE may be potentiated and these IgE may interfere in passive sensitization of mast cells with IgE antibodies. The examination of rats also showed, that mast cells with lower concentration of non-specific IgE are better acceptors for sensitization with IgE antibodies.
对近交系BALB/c、129、C3H/A、C57BL/6J小鼠以及远交系Wistar大鼠进行了检测，以观察它们对抗原刺激产生反应时的反应素致敏能力。免疫前测得的总血清IgE水平在129小鼠中最高，免疫后升高（2.5至3倍）。BALB/c小鼠免疫后总血清IgE也有所增加，而在其他两个品系中未观察到这种效应。所有测试的小鼠品系免疫后均产生IgE抗体，结果表明，这些IgE抗体在免疫期间仅占总IgE含量的一小部分；在129和BALB/c小鼠中，除了IgE抗体反应外，非特异性IgE的产生可能会增强，这些IgE可能会干扰肥大细胞与IgE抗体的被动致敏。对大鼠的检测还表明，非特异性IgE浓度较低的肥大细胞是IgE抗体致敏的更好受体。
