The relation between magnesium, blood histamine level and eosinophilia in the acute stage of the allergic reactions in humans.

Investigation of magnesium, blood histamine level and eosinophilia were carried out on 28 bronchial asthma patients during the exacerbation of asthma and in asymptomatic period of the disease. Control group consisted of 30 healthy persons. It was found that during asthma attack in the patients with atopic asthma magnesium level in blood and erythrocytes decreased which is correlated to the rise in histamine level and the number of eosinophils in blood. This relationship was less marked in patients with non-atopic asthma. Results obtained are a further confirmation of the role of magnesium ions in the pathomechanism of immediate allergic reactions in humans and its participation in the immunological release of histamine.