Calleri G, Dassio G
Divisione A Malattie Infettive, Ospedale Amedeo di Savoia, Torino.
G Batteriol Virol Immunol. 1992;85(1-12):47-54.
Alpha Interferon showed effective in the treatment of chronic type C hepatitis, but a consensus has not been reached about the selection of patients and therapy schedules so far. We treated 36 patients with chronic type C hepatitis in the outpatient ward of the 1st Infectious Diseases Dept., "Amedeo di Savoia" Hospital, Torino (Head of Dept.: Prof. W. Grillone) in the period 1990-1992. Alpha IFN 1-6 MU thrice weekly for 6-12 months was used. The average follow up period after therapy was 8.5 months. Four patients dropped out during the treatment period. The clinical response was evaluated using serum transaminases: 9 patients showed a full response, 9 patients had a hepatitis relapse after stopping the treatment, 6 patients had a partial response, and 9 were treatment failures. A better response was observed in young patients, drug addicts, with chronic persistent hepatitis and high transaminases levels. Side effects of the treatment were very frequent, but usually short lasting, and seldom responsible for dropping out.
α干扰素在慢性丙型肝炎的治疗中显示出有效性，但迄今为止，在患者选择和治疗方案方面尚未达成共识。1990年至1992年期间，我们在都灵“Amedeo di Savoia”医院第一传染病科门诊病房（科室主任：W. Grillone教授）对36例慢性丙型肝炎患者进行了治疗。使用α干扰素1 - 6 MU，每周三次，共6 - 12个月。治疗后的平均随访期为8.5个月。4例患者在治疗期间退出。使用血清转氨酶评估临床反应：9例患者显示完全缓解，9例患者在停药后肝炎复发，6例患者部分缓解，9例治疗失败。在年轻患者、吸毒者、慢性持续性肝炎患者和转氨酶水平高的患者中观察到更好的反应。治疗的副作用非常常见，但通常持续时间较短，很少导致退出治疗。
