对乙酰胆碱酯酶抑制剂具有抗性的秀丽隐杆线虫突变体。
Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase.
作者信息
Nguyen M, Alfonso A, Johnson C D, Rand J B
机构信息
Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA.
出版信息
Genetics. 1995 Jun;140(2):527-35. doi: 10.1093/genetics/140.2.527.
Abstract
We characterized 18 genes from Caenorhabditis elegans that, when mutated, confer recessive resistance to inhibitors of acetylcholinesterase. These include previously described genes as well as newly identified genes; they encode essential as well as nonessential functions. In the absence of acetylcholinesterase inhibitors, the different mutants display a wide range of behavioral deficits, from mild uncoordination to almost complete paralysis. Measurements of acetylcholine levels in these mutants suggest that some of the genes are involved in presynaptic functions.
摘要
我们对秀丽隐杆线虫的18个基因进行了特征分析，这些基因发生突变时会对乙酰胆碱酯酶抑制剂产生隐性抗性。其中包括先前已描述的基因以及新鉴定出的基因；它们编码必需和非必需功能。在没有乙酰胆碱酯酶抑制剂的情况下，不同的突变体表现出广泛的行为缺陷，从轻度不协调到几乎完全瘫痪。对这些突变体中乙酰胆碱水平的测量表明，其中一些基因参与突触前功能。
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