Spencer J L, Gavora J S, Grunder A A, Robertson A, Speckmann G W
Avian Dis. 1976 Apr-Jun;20(2):286-92.
Transmissible lymphoid tumor (TLT) was inoculated in wing webs of five-week-old chickens of 6 strains. About half of the chickens of each strain had been vaccinated with turkey herpesvirus (HVT) one week before challenge in the wing web with TLT. Tumors which developed at the site of inoculation usually reached maximum size within 2 weeks and then regressed. In some chickens, however, tumors developed in visceral organs and caused death in the 2nd through 5th weeks postinoculation. Comparisons among strains of chickens in Expt. 1 revealed no differences in mortality. Vaccination with HVT reduced mortality and also the incidence of wing-web tumors (WWT) in all strains of chickens. A lymphoid leukosis virus and a Marek's disease (MD) virus of low virulence were detected in preparations of TLT, and it is suggested that the immunity induced by vaccination may have been directed against tumor antigens associated with MD virus.
将可传播性淋巴细胞瘤（TLT）接种到6个品系的5周龄鸡的翼蹼中。每个品系约一半的鸡在翼蹼接种TLT前一周用火鸡疱疹病毒（HVT）进行了免疫接种。接种部位出现的肿瘤通常在2周内达到最大尺寸，然后消退。然而，在一些鸡中，内脏器官出现肿瘤并在接种后第2周至第5周导致死亡。实验1中鸡品系间的比较显示死亡率没有差异。用HVT免疫接种降低了所有品系鸡的死亡率以及翼蹼肿瘤（WWT）的发生率。在TLT制剂中检测到一种淋巴细胞白血病病毒和一种低毒力的马立克氏病（MD）病毒，提示免疫接种诱导的免疫可能针对与MD病毒相关的肿瘤抗原。
