Paul C, Bolton C
Pharmacology Group, School of Pharmacy and Pharmacology, University of Bath, U.K.
Int J Immunopharmacol. 1995 Jun;17(6):497-503. doi: 10.1016/0192-0561(95)00034-y.
Double radioisotope measurement of neurovascular integrity in Lewis rats inoculated for experimental allergic encephalomyelitis (EAE) showed abnormal elevation of albumin extravasation in the cerebellum, medulla-pons and cervical spinal cord at the time of clinical manifestation. Therapeutically administered dexamethasone (Dex) (0.1-1 mg/kg body weight) or cyclosporin A (CsA) (25-75 mg/kg body weight) dose-dependently reduced albumin movement across the blood-brain barrier (BBB). Dex at a dose of 1 mg/kg completely suppressed abnormal BBB permeability in all tissues (P < or = 0.001), while CsA at the highest dose of 75 mg/kg achieved highly significant (P < or = 0.001), but not complete, suppression of aberrant barrier leakage in the areas studied. The implications of these findings to possible drug action at the immunocompromised cerebrovasculature are discussed.
对接种实验性变态反应性脑脊髓炎（EAE）的Lewis大鼠进行双放射性同位素神经血管完整性测量显示，在临床表现期，小脑、延髓脑桥和颈脊髓中的白蛋白外渗异常升高。治疗性给予地塞米松（Dex）（0.1 - 1mg/kg体重）或环孢素A（CsA）（25 - 75mg/kg体重）可剂量依赖性地减少白蛋白穿过血脑屏障（BBB）的移动。剂量为1mg/kg的Dex完全抑制了所有组织中异常的BBB通透性（P≤0.001），而最高剂量为75mg/kg的CsA对所研究区域异常的屏障渗漏实现了高度显著（P≤0.001）但非完全的抑制。讨论了这些发现对免疫受损脑血管可能的药物作用的影响。
