Bertelli A A, Giovannini L, Giannessi D, Migliori M, Bernini W, Fregoni M, Bertelli A
Institute of Anatomy, University of Milan, Italy.
Int J Tissue React. 1995;17(1):1-3.
The antiaggregating effect of the phytoalexin resveratrol (3,4,5-trihydroxystilbene), alone or associated with red wine, and polyphenol have been evaluated in vitro at different concentrations on platelet-rich plasma from healthy volunteers. Resveratrol at the concentration of 3.56 micrograms/l was able to lower platelet aggregation by 50.3% +/- 1.83. Red wine containing 1.2 mg/l of natural trans-resveratrol and 3.6 milligrams of polyphenols diluted 1000-fold (final resveratrol concentration: 1.2 micrograms/l) inhibited platelet aggregation by 41.9% +/- 2.11. By adding resveratrol to the wine up to a concentration of 1.2 micrograms/l, inhibition was raised to 78.5% +/- 4.70. These results suggest that the antiaggregating activity of resveratrol is related to its concentration in wine.
已在体外对来自健康志愿者的富血小板血浆，以不同浓度评估了植物抗毒素白藜芦醇（3,4,5 - 三羟基芪）单独或与红酒及多酚联合时的抗聚集作用。浓度为3.56微克/升的白藜芦醇能够使血小板聚集降低50.3%±1.83。含有1.2毫克/升天然反式白藜芦醇和3.6毫克多酚的红酒稀释1000倍（最终白藜芦醇浓度：1.2微克/升）可抑制血小板聚集41.9%±2.11。通过向红酒中添加白藜芦醇至浓度达到1.2微克/升，抑制率提高至78.5%±4.70。这些结果表明白藜芦醇的抗聚集活性与其在红酒中的浓度有关。
