Das D K, Sato M, Ray P S, Maulik G, Engelman R M, Bertelli A A, Bertelli A
University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA.
Drugs Exp Clin Res. 1999;25(2-3):115-20.
Epidemiological studies suggest that the consumption of wine, particularly of red wine, reduces the incidence of mortality and morbidity from coronary heart disease. This has given rise to what is now popularly termed the "French paradox". The cardioprotective effect has been attributed to antioxidants present in the polyphenol fraction of red wine. Grapes contain a variety of antioxidants, including resveratrol, catechin, epicatechin and proanthocyanidins. Of these, resveratrol is present mainly in grape skin while proanthocyanidin is present in the seeds. In this report, we provide evidence that red wine extract as well as resveratrol and proanthocyanidins are equally effective in reducing myocardial ischemic reperfusion injury, which suggests that these red wine polyphenolic antioxidants play a crucial role in cardioprotection.
流行病学研究表明，饮用葡萄酒，尤其是红酒，可降低冠心病的死亡率和发病率。这引发了如今广为人知的“法国悖论”。心脏保护作用归因于红酒多酚部分中的抗氧化剂。葡萄含有多种抗氧化剂，包括白藜芦醇、儿茶素、表儿茶素和原花青素。其中，白藜芦醇主要存在于葡萄皮中，而原花青素存在于葡萄籽中。在本报告中，我们提供证据表明红酒提取物以及白藜芦醇和原花青素在减轻心肌缺血再灌注损伤方面同样有效，这表明这些红酒多酚抗氧化剂在心脏保护中起关键作用。
