脾红细胞池积：红细胞增多症的一项诊断特征。

Splenic red cell pooling: a diagnostic feature in polycythaemia.

作者信息

Bateman S, Lewis S M, Nicholas A, Zaafran A

出版信息

Br J Haematol. 1978 Nov;40(3):389-96. doi: 10.1111/j.1365-2141.1978.tb05810.x.

DOI:10.1111/j.1365-2141.1978.tb05810.x

Abstract

Total red cell volumes and splenic red cell pools were measured in 31 patients with polycythaemia. 22 had polycythaemia vera (PV), 12 of whom had clinically detectable splenomegaly, and nine patients had secondary polycythaemia (PS). The mean red cell pool was 192.8 ml (SD 126.6) in PV (all cases), and 130.9 ml (SD 28.4 ml) in PV without splenomegaly; it was 61.1 ml (SD 8.3 ml) in PS. When expressed relative to spleen size (in cm), differences were even more striking: PV (all cases)--mean 13.7 ml/cm (SD 4.3); PV without splenomegaly--mean 12.7 ml/cm (SD 2.2); PS--mean 6.6 ml/cm (SD 1.2). Measurement of splenic red cell pool thus appears to be a valuable diagnostic tool for distinguishing between PV and PS. The findings point to the presence in PV of a splenic structural abnormality which is not simply an effect of the increased circulating red cell mass.

摘要

对31例红细胞增多症患者测量了全红细胞体积和脾脏红细胞池。22例为真性红细胞增多症（PV），其中12例临床上可检测到脾肿大，9例为继发性红细胞增多症（PS）。PV（所有病例）的平均红细胞池为192.8 ml（标准差126.6），无脾肿大的PV患者平均红细胞池为130.9 ml（标准差28.4 ml）；PS患者的平均红细胞池为61.1 ml（标准差8.3 ml）。当相对于脾脏大小（以厘米为单位）表示时，差异更为显著：PV（所有病例）——平均13.7 ml/cm（标准差4.3）；无脾肿大的PV——平均12.7 ml/cm（标准差2.2）；PS——平均6.6 ml/cm（标准差1.2）。因此，测量脾脏红细胞池似乎是区分PV和PS的一种有价值的诊断工具。这些发现表明PV存在脾脏结构异常，而这不仅仅是循环红细胞量增加的结果。