慢性甲状腺炎和甲状腺乳头状癌中细胞增殖活性增强及细胞死亡
Enhanced cellular proliferative activity and cell death in chronic thyroiditis and thyroid papillary carcinoma.
作者信息
Okayasu I, Saegusa M, Fujiwara M, Hara Y, Rose N R
机构信息
Department of Pathology, School of Medicine, Kitasato University, Kanagawa, Japan.
出版信息
J Cancer Res Clin Oncol. 1995;121(12):746-52. doi: 10.1007/BF01213321.
Abstract
For the analysis of cellular proliferative activity and cell death in thyroid diseases, the Ki-67 labeling index, bcl-2 protein expression and cell death of follicular epithelia by immunohistochemistry and in situ DNA nick-end labeling methods were evaluated in normal thyroid tissues as well as in surgical specimens from cases of Hashimoto's disease (16 cases), focal lymphocytic thyroiditis (13 cases), Graves' disease (15 cases), follicular adenoma (20 cases) and papillary carcinoma (43 cases). Cellular proliferative activity and cell death were both enhanced in cases of thyroiditis, including Hashimoto's disease and focal lymphocytic thyroiditis. Thyroids from patients with follicular adenoma and papillary carcinoma also showed increased cellular proliferative activity and cell death. In addition, predominant high cellularity and partial loss of bcl-2 protein expression in papillary carcinoma suggested that the overgrowth and dedifferentiation were associated with malignancy.
摘要
为分析甲状腺疾病中的细胞增殖活性和细胞死亡情况，采用免疫组织化学和原位DNA缺口末端标记法，对正常甲状腺组织以及桥本氏病（16例）、局灶性淋巴细胞性甲状腺炎（13例）、格雷夫斯病（15例）、滤泡性腺瘤（20例）和乳头状癌（43例）手术标本中的Ki-67标记指数、bcl-2蛋白表达及滤泡上皮细胞死亡情况进行了评估。甲状腺炎病例（包括桥本氏病和局灶性淋巴细胞性甲状腺炎）的细胞增殖活性和细胞死亡均增强。滤泡性腺瘤和乳头状癌患者的甲状腺也显示出细胞增殖活性和细胞死亡增加。此外，乳头状癌中主要的高细胞密度和bcl-2蛋白表达的部分缺失表明，过度生长和去分化与恶性肿瘤有关。
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