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月经周期中正常子宫内膜的Bcl-2表达

Bcl-2 expression in normal endometrium during the menstrual cycle.

作者信息

Gompel A, Sabourin J C, Martin A, Yaneva H, Audouin J, Decroix Y, Poitout P

机构信息

Departement de Gynécologie et Obstétrique, Hôpital Hotel Dieu, Paris, France.

出版信息

Am J Pathol. 1994 Jun;144(6):1195-202.

PMID:8203460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1887458/
Abstract

Bcl-2 is a proto-oncogene initially described in the (14;18) translocation in follicular lymphoma. It has been shown to prolong cell survival by preventing apoptosis. Endometrium undergoes rapid proliferation and differentiation under hormone control and is thus an excellent model to study the hormone dependency of Bcl-2 expression. We studied Bcl-2 expression by an immunohistochemical method in 53 samples of normal endometrium randomly distributed throughout the menstrual cycle, as well as five samples of hyperplastic endometrium. Bcl-2 staining predominated in glandular cells and peaked at the end of the follicular phase. Bcl-2 expression disappeared at the onset of secretory activity. The stroma, surface lining epithelium and arterial vessels also displayed cyclic variations in Bcl-2 expression. These results strongly suggest hormone-dependent regulation of Bcl-2 expression, which could play an important role in tumorigenesis.

摘要

Bcl-2是一种原癌基因，最初在滤泡性淋巴瘤的（14；18）易位中被描述。已证明它通过防止细胞凋亡来延长细胞存活时间。子宫内膜在激素控制下经历快速增殖和分化，因此是研究Bcl-2表达激素依赖性的理想模型。我们采用免疫组化方法研究了53例在整个月经周期随机分布的正常子宫内膜样本以及5例增生性子宫内膜样本中的Bcl-2表达。Bcl-2染色在腺细胞中占主导，在卵泡期结束时达到峰值。在分泌活动开始时Bcl-2表达消失。基质、表面衬里上皮和动脉血管的Bcl-2表达也呈现周期性变化。这些结果强烈提示Bcl-2表达受激素依赖性调节，这可能在肿瘤发生中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/277929649834/amjpathol00066-0088-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/ed0c05f01b6e/amjpathol00066-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/5f1c5006a1dd/amjpathol00066-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/3b4cc1d72ee3/amjpathol00066-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/828ceb4f3e44/amjpathol00066-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/c66fc78896b8/amjpathol00066-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/277929649834/amjpathol00066-0088-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/ed0c05f01b6e/amjpathol00066-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/5f1c5006a1dd/amjpathol00066-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/3b4cc1d72ee3/amjpathol00066-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/828ceb4f3e44/amjpathol00066-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/c66fc78896b8/amjpathol00066-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/082f/1887458/277929649834/amjpathol00066-0088-b.jpg

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本文引用的文献

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bcl-2 inhibits death of central neural cells induced by multiple agents.bcl-2抑制多种因素诱导的中枢神经细胞死亡。
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Bcl-2 expression in adult and embryonic non-haematopoietic tissues.Bcl-2在成年和胚胎非造血组织中的表达。
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Topographical dissociation of BCL-2 messenger RNA and protein expression in human lymphoid tissues.人淋巴组织中BCL-2信使核糖核酸与蛋白表达的拓扑解离
绝经后女性子宫内膜息肉中BCL2和MKI67的表达水平及其与肥胖的相关性。
Mol Clin Oncol. 2020 Dec;13(6):69. doi: 10.3892/mco.2020.2139. Epub 2020 Sep 17.
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Structural equation modelling analysis determining causal role among methyltransferases, methylation, and apoptosis during human pregnancy and abortion.结构方程模型分析在人类妊娠和流产期间确定甲基转移酶、甲基化和细胞凋亡之间的因果关系。
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Bcl-2 may play a role in the progression of endometrial hyperplasia and early carcinogenesis, but not linked to further tumorigenesis.Bcl-2可能在子宫内膜增生和早期癌变过程中发挥作用，但与进一步的肿瘤发生无关。
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