Laubach M G, Woodward D J
Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157, USA.
J Comp Neurol. 1995 Sep 11;360(1):49-58. doi: 10.1002/cne.903600105.
The goal of this study was to determine the compartmental organization of 5'-nucleotidase within the rodent ventral striatum and to compare the distribution of 5'-nucleotidase with that of leu-enkephalin, cell clusters, and infralimbic cortical innervation. In the core, 5'-nucleotidase is present in several contiguous patchy structures that are in register with leu-enkephalin compartments. In the shell, 5'-nucleotidase is concentrated in a longitudinal band along the septal border. This "medial band" extends from the rostral pole of the ventral striatum to the bed nucleus of stria terminalis. The ventral portion of the medial band is in register with a cluster of cells, located medial to the most dorsal island of Cajella. A second 5'-nucleotidase compartment along the border of the core and shell is in register with a cell cluster and is most evident at caudal levels of the ventral striatum. The innervation of the ventral striatum by the infralimbic cortex is denser in the shell than in the core. In the shell, fibers from the superficial layers of the infralimbic cortex tend to avoid the 5'-nucleotidase-rich cell clusters and terminate in areas of moderate 5'-nucleotidase density. By contrast, fibers from the deep layers terminate in the ventral striatum without regard to the 5'-nucleotidase-rich cell clusters. Overall, the compartmental structure of 5'-nucleotidase in the ventral striatum segregates projections from different layers of the infralimbic cortex. Dense 5'-nucleotidase compartments are innervated by neurons in the deep layers of the infralimbic cortex. The area of moderate 5'-nucleotidase density surrounding the 5'-nucleotidase compartments is innervated by neurons in both the superficial and deep layers.
本研究的目的是确定啮齿动物腹侧纹状体内5'-核苷酸酶的分区组织，并比较5'-核苷酸酶与亮脑啡肽、细胞簇和边缘下皮质神经支配的分布情况。在核心区域，5'-核苷酸酶存在于几个连续的斑块状结构中，这些结构与亮脑啡肽分区对齐。在壳区域，5'-核苷酸酶集中在沿隔区边界的一条纵带上。这条“内侧带”从腹侧纹状体的嘴侧极延伸至终纹床核。内侧带的腹侧部分与位于最背侧的卡耶拉岛内侧的一群细胞对齐。沿着核心和壳边界的第二个5'-核苷酸酶分区与一个细胞簇对齐，在腹侧纹状体的尾侧水平最为明显。边缘下皮质对腹侧纹状体的神经支配在壳区域比在核心区域更密集。在壳区域，来自边缘下皮质浅层的纤维倾向于避开富含5'-核苷酸酶的细胞簇，并终止于5'-核苷酸酶密度中等的区域。相比之下，来自深层的纤维在腹侧纹状体中终止，而不考虑富含5'-核苷酸酶的细胞簇。总体而言，腹侧纹状体内5'-核苷酸酶的分区结构将来自边缘下皮质不同层的投射区分开来。密集的5'-核苷酸酶分区由边缘下皮质深层的神经元支配。围绕5'-核苷酸酶分区的5'-核苷酸酶密度中等的区域由浅层和深层的神经元支配。
