Pilorget H, Alessandri J L, Montbrun A, Ah-Hot M, Orvain E, Tilmont P
Service de Néonatologie et Réanimation Néonatale et Pédiatrique, Centre Hospitalier, Saint-Denis, La Réunion.
J Gynecol Obstet Biol Reprod (Paris). 1995;24(5):511-5.
Retinoids are synthetic vitamin A derivatives, particularly used in dermatology. Their prescription in women of childbearing age can cause, if pregnancy occurs, a serious malformative embryopathy, mainly involving external ear, brain and heart. A neonatal case caused by isotretinoin (RoAccutane) emphasizes the clinical and epidemiological data concerning this embryopathy. The aetiopathological hypothesis of an interaction between isotretinoin and Hox genes is advanced. Prophylactic measures are difficult since neonatal reported cases are uncommon, but antenatal exposition to this strong teratogenic agent results in multiple spontaneous abortions or pregnancy interruptions.
维甲酸是合成的维生素A衍生物，特别用于皮肤科。在育龄妇女中开具这类药物的处方，如果发生怀孕，可能会导致严重的致畸性胚胎病，主要累及外耳、脑和心脏。一例由异维甲酸（罗可坦）引起的新生儿病例强调了关于这种胚胎病的临床和流行病学数据。提出了异维甲酸与Hox基因相互作用的病因病理假说。由于新生儿报告病例不常见，预防措施很难实施，但产前接触这种强致畸剂会导致多次自然流产或妊娠中断。
