Pons J C, Ville Y, Imbert M C, Thomas A, Frydman R, Benifla J L
Service de Gynécologie-Obstétrique, Höpital Antoine-Béclère, Clamart.
J Gynecol Obstet Biol Reprod (Paris). 1996;25(3):274-6.
We report on 2 women who were treated with retinoids (Roaccutan, isotretinoin) during the first trimester of their pregnancies. Therapeutic abortions were carried out. The interest in these case reports lies in the determination of concentration of isotretinoin and its metabolites (4-oxo-isotretinoin, and tretinoin) in foetal tissues, using high performance liquid chromatography. The findings show the significant transplacental passage of isotretinoin, an accumulation of 4-oxo-isotretinoin in the liver, and a low concentration of retinoids in the brain of these foetuses. Contraception must be used with retinoid treatment and for 4 weeks after retinoid withdrawal.
我们报告了2名在妊娠头三个月接受维甲酸（Roaccutan，异维甲酸）治疗的女性。她们进行了治疗性流产。这些病例报告的意义在于使用高效液相色谱法测定胎儿组织中异维甲酸及其代谢物（4-氧代异维甲酸和维甲酸）的浓度。研究结果表明异维甲酸有显著的经胎盘转运，4-氧代异维甲酸在肝脏中蓄积，且这些胎儿大脑中的维甲酸浓度较低。使用维甲酸治疗期间及停药后4周必须采取避孕措施。
