Leviton A, Bellinger D, Pagano M, Rabinowitz M
Children's Hospital, Harvard Medical School, Boston, MA, USA.
J Child Neurol. 1995 Sep;10(5):385-91. doi: 10.1177/088307389501000509.
After a biologic insult has impaired function of the developing central nervous system, recovery may not become apparent for years. Probability models adopted from the carcinogenesis, developmental neurobiology, learning decay, and stochastic process literatures are presented so that assumptions about apparent delays in the recovery process can be tested with data from longitudinal studies after a temporally circumscribed adverse event/exposure. This process of evaluating multiple models is exemplified with one data set. Nonlinear models of recovery are important because some children with early deficits first show improvement months to years later.
在生物性损伤损害发育中的中枢神经系统功能后，恢复情况可能在数年内都不明显。本文介绍了从癌症发生、发育神经生物学、学习衰退和随机过程文献中采用的概率模型，以便可以利用在一个时间限定的不良事件/暴露后进行的纵向研究数据，来检验关于恢复过程中明显延迟的假设。用一个数据集举例说明了评估多个模型的这个过程。恢复的非线性模型很重要，因为一些早期有缺陷的儿童最初在数月至数年之后才会出现改善。
