相似文献

1

A transforming growth factor beta-like immunosuppressive factor in immunoglobulin G-binding factor.

J Exp Med. 1995 Dec 1;182(6):1717-26. doi: 10.1084/jem.182.6.1717.

2

Transforming growth factor-beta 1 is required for secretion of IgG of all subclasses by LPS-activated murine B cells in vitro.

J Immunol. 1993 Nov 1;151(9):4625-36.

3

Murine IgA binding factors (IgA-BF) suppressing IgA production: characterization and target specificity of IgA-BF.

J Immunol. 1986 Apr 15;136(8):2910-6.

4

Murine IgA binding factors produced by Fc alpha R(+) T cells: role of Fc gamma R(+) cells for the induction of Fc alpha R and formation of IgA-binding factor in Con A-activated cells.

J Immunol. 1984 Jul;133(1):65-71.

5

Immunoglobulin G-binding factors (IgG-BF) inhibit IgG secretion by, as well as proliferation of, hybridoma B cells.

Immunol Lett. 1987 Nov;16(2):139-44. doi: 10.1016/0165-2478(87)90121-0.

6

Mechanism of inhibition of lipopolysaccharide-stimulated mouse B-cell responses by transforming growth factor-beta 1.

Immunol Lett. 1994 May;40(2):105-10. doi: 10.1016/0165-2478(94)90180-5.

7

Suppression of polyclonal B cell activation by IgG-binding factors. Requirement for T cells.

Eur J Immunol. 1985 Jan;15(1):96-9. doi: 10.1002/eji.1830150119.

8

Immunoregulatory effects of transforming growth factor-beta in a prolonged period of culture.

Cell Immunol. 1992 Jan;139(1):239-47. doi: 10.1016/0008-8749(92)90116-7.

9

Transforming growth factor beta 1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells.

J Exp Med. 1993 Apr 1;177(4):1031-7. doi: 10.1084/jem.177.4.1031.

10

Concentration-dependent bifunctional effect of TGF-beta 1 on immunoglobulin production: a role for Smad3 in IgA production in vitro.

Int Immunopharmacol. 2003 Dec;3(13-14):1761-74. doi: 10.1016/j.intimp.2003.08.001.

引用本文的文献

1

Fcγ Receptor Heterogeneity in Leukocyte Functional Responses.

Front Immunol. 2017 Mar 20;8:280. doi: 10.3389/fimmu.2017.00280. eCollection 2017.

2

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins.

Cold Spring Harb Perspect Biol. 2016 Jun 1;8(6):a021907. doi: 10.1101/cshperspect.a021907.

3

Circulating immunoglobulin-bound transforming growth factor beta at a late tumour-bearing stage impairs antigen-specific responses of CD4+ T cells.

Clin Exp Immunol. 2002 May;128(2):204-12. doi: 10.1046/j.1365-2249.2002.01806.x.

4

An antibody present in normal human serum inhibits the binding of cytokines to their receptors in an in vitro system.

Biochem J. 1999 Oct 1;343 Pt 1(Pt 1):125-33.

5

Intracellular demonstration of active TGFbeta1 in B cells and plasma cells of autoimmune mice. IgG-bound TGFbeta1 suppresses neutrophil function and host defense against Staphylococcus aureus infection.

J Clin Invest. 1996 Dec 1;98(11):2496-506. doi: 10.1172/JCI119068.

本文引用的文献

1

Activation of latent transforming growth factor beta.

Adv Pharmacol. 1993;24:51-76. doi: 10.1016/s1054-3589(08)60933-3.

2

Recombinant human transforming growth factor-beta 1: expression by Chinese hamster ovary cells, isolation, and characterization.

Protein Expr Purif. 1993 Apr;4(2):130-40. doi: 10.1006/prep.1993.1019.

3

Transforming growth factor beta 1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells.

J Exp Med. 1993 Apr 1;177(4):1031-7. doi: 10.1084/jem.177.4.1031.

4

Identification, in mouse macrophages and in serum, of a soluble receptor for the Fc portion of IgG (Fc gamma R) encoded by an alternatively spliced transcript of the Fc gamma RII gene.

Int Immunol. 1993 Aug;5(8):859-68. doi: 10.1093/intimm/5.8.859.

5

Mechanism and regulation of immunoglobulin isotype switching.

Adv Immunol. 1993;54:229-70. doi: 10.1016/s0065-2776(08)60536-2.

6

A first or dominant immunization. II. Induced immunoglobulin carries transforming growth factor beta and suppresses cytolytic T cell responses to unrelated alloantigens.

J Exp Med. 1993 Sep 1;178(3):841-52. doi: 10.1084/jem.178.3.841.

7

TGF-beta receptors: a complicated system of multiple binding proteins.

Biochim Biophys Acta. 1993 Dec 23;1155(3):269-75. doi: 10.1016/0304-419x(93)90009-2.

8

Soluble Fc gamma receptors.

J Leukoc Biol. 1993 Nov;54(5):504-12.

9

TGF-beta mediates natural suppressor activity of IL-2-activated lymphocytes.

J Immunol. 1994 Apr 15;152(8):3842-7.

10

Transforming growth factor beta: a matter of life and death.

J Leukoc Biol. 1994 Mar;55(3):401-9. doi: 10.1002/jlb.55.3.401.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。

免疫球蛋白G结合因子中的一种转化生长因子β样免疫抑制因子。

A transforming growth factor beta-like immunosuppressive factor in immunoglobulin G-binding factor.

作者信息

Bouchard C, Galinha A, Tartour E, Fridman W H, Sautès C

机构信息

Laboratoire d'Immunologie Cellulaire et Clinique, INSERM U255, Institut Curie, Paris, France.

出版信息

J Exp Med. 1995 Dec 1;182(6):1717-26. doi: 10.1084/jem.182.6.1717.

DOI:10.1084/jem.182.6.1717

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2192234/

Abstract

Immunoglobulin G-binding factors (IgG-BF), which are produced by cells of the immune system, inhibit antibody production. In this paper, we show that transforming growth factor-beta (TGF-beta) suppresses secondary in vitro anti-sheep red blood cell responses of mouse splenocytes and lipopolysaccharide- or anti-IgM-stimulated mouse B cell responses in a way similar to, and with the same kinetics as, rodent IgG-BF. Moreover, the immunosuppressive activity of IgG-BF was totally neutralized by polyclonal and monoclonal anti-TGF-beta antibodies and it eluted with TGF-beta by gel exclusion chromatography, suggesting that a TGF-beta-like immunosuppressive factor is present in IgG-BF. We also show that TGF-beta behaves as an IgG-BF since it binds to insolubilized IgG, but not to insolubilized F(ab')2 or bovine serum albumin. Altogether, the data support the concept of a biological role for TGF-beta in the IgG-mediated negative feedback of antibody responses.

摘要

由免疫系统细胞产生的免疫球蛋白G结合因子（IgG-BF）可抑制抗体产生。在本文中，我们表明转化生长因子-β（TGF-β）以类似于啮齿动物IgG-BF的方式并具有相同的动力学，抑制小鼠脾细胞的体外继发性抗绵羊红细胞反应以及脂多糖或抗IgM刺激的小鼠B细胞反应。此外，IgG-BF的免疫抑制活性被多克隆和单克隆抗TGF-β抗体完全中和，并且它通过凝胶排阻色谱法与TGF-β一起洗脱，这表明IgG-BF中存在一种类似TGF-β的免疫抑制因子。我们还表明，TGF-β表现为一种IgG-BF，因为它能结合固定化的IgG，但不结合固定化的F(ab')2或牛血清白蛋白。总之，这些数据支持了TGF-β在IgG介导的抗体反应负反馈中具有生物学作用的概念。