Kim S G
Department of Radiology, University of Minnesota Medical School, Minneapolis 55455, USA.
Magn Reson Med. 1995 Sep;34(3):293-301. doi: 10.1002/mrm.1910340303.
Relative cerebral blood flow changes can be measured by a novel simple blood flow measurement technique with endogenous water protons as a tracer based on flow-sensitive alternating inversion recovery (FAIR). Two inversion recovery (IR) images are acquired by interleaving slice-selective inversion and nonselective inversion. During the inversion delay time after slice-selective inversion, fully magnetized blood spins move into the imaging slice and exchange with tissue water. The signal enhancement (FAIR image) measured by the signal difference between two images is directly related to blood flow. For functional MR imaging studies, two IR images are alternatively and repeatedly acquired during control and task periods. Relative signal changes in the FAIR images during the task periods represent the relative regional cerebral blood flow changes. The FAIR technique has been successfully applied to functional brain mapping studies in humans during finger opposition movements. The technique is capable of generating microvascular-based functional maps.
相对脑血流量变化可通过一种新型的简单血流测量技术来测量，该技术以内生水质子作为示踪剂，基于流动敏感交替反转恢复（FAIR）。通过交错切片选择性反转和非选择性反转来采集两幅反转恢复（IR）图像。在切片选择性反转后的反转延迟时间内，完全磁化的血液自旋进入成像切片并与组织水进行交换。通过两幅图像之间的信号差异测量得到的信号增强（FAIR图像）与血流量直接相关。对于功能磁共振成像研究，在对照期和任务期交替且重复地采集两幅IR图像。任务期FAIR图像中的相对信号变化代表相对局部脑血流量变化。FAIR技术已成功应用于人类手指对指运动期间功能脑图谱研究。该技术能够生成基于微血管的功能图谱。
