Clarenbach P, Steinberg R, Weess H G, Berger M
Neurologische Klinik, Evangelisches Johannes-Krankenhaus, Bielefeld.
Nervenarzt. 1995 Oct;66(10):723-9.
There exist a variety of American and European recommendations regarding treatment with hypnotics, especially the duration of treatment. The German Sleep Society now publishes its own view to help physicians to cope with these different recommendations, some of which are contradictory. Therapy with hypnotics must include substantial information on the type of drug, dose, timing and duration as well as information about the possibility of interval treatment. Agonists at the benzodiazepine receptor, like the conventional benzodiazepines and zopiclone or zolpideme, are indicated in short-lasting adjustment insomnia as well as in long-lasting psychophysiological insomnia. Regarding the duration of prescription the German Sleep Society recommends a period of 14 days in de novo patients, which can be repeated once only. In persisting insomnias further approaches should disregard benzodiazepine receptor agonists, but rely on other classes of substances such as tricyclic antidepressants instead. If such approaches are ineffective, the intake of benzodiazepine receptor agonists may be extended to 6 months, when a sleep log and objective observations have documented a true sleep deficit, when daytime impairment arises, when daytime impairment arises, when rebound insomnia, organic or mental insomnias and dependencies have been excluded, and when the indication is monitored at 14-day intervals. If the insomnia persists, during and in spite of therapy a specialist in sleep medicine should be consulted. If therapy is still ineffective after 3 months of daily treatment, a sleep laboratory should be consulted.
关于使用催眠药物进行治疗,尤其是治疗时长,美国和欧洲有各种各样的建议。德国睡眠协会现在公布其自身观点,以帮助医生应对这些不同的建议,其中一些建议相互矛盾。使用催眠药物进行治疗必须包括关于药物类型、剂量、服药时间和疗程的大量信息,以及关于间歇性治疗可能性的信息。苯二氮䓬受体激动剂,如传统的苯二氮䓬类药物、佐匹克隆或唑吡坦,适用于短期适应性失眠以及长期心理生理性失眠。关于处方疗程,德国睡眠协会建议初诊患者为14天,且只能重复一次。对于持续性失眠,进一步的治疗方法不应使用苯二氮䓬受体激动剂,而应依赖其他类别的药物,如三环类抗抑郁药。如果这些方法无效,当睡眠日志和客观观察记录了真正的睡眠不足、出现日间功能损害、排除了反弹性失眠、器质性或精神性失眠及药物依赖,且每隔14天对适应证进行监测时,苯二氮䓬受体激动剂的服用时间可延长至6个月。如果失眠持续存在,无论治疗期间还是治疗后,都应咨询睡眠医学专家。如果每日治疗3个月后治疗仍无效,应咨询睡眠实验室。