急性给予血管紧张素II可改善招潮蟹的长期习性化。

Acute administration of angiotensin II improves long-term habituation in the crab Chasmagnathus.

作者信息

Delorenzi A, Pedreira M E, Romano A, Pirola C J, Nahmod V E, Maldonado H

机构信息

Facultad de Ciencias Exactas y Naturales, Depto Biología, Universidad de Buenos Aires (1428), Argentina.

出版信息

Neurosci Lett. 1995 Aug 25;196(3):193-6. doi: 10.1016/0304-3940(95)11876-x.

DOI:10.1016/0304-3940(95)11876-x

PMID:7501281

Abstract

A shadow moving overhead acts as a danger stimulus and elicits an escape response in the crab Chasmagnathus granulatus that habituates after 15 trials and for a long period. A shorter training of ten trials fails to induce long-term habituation; however, a good retention of the habituated response is manifest after a 24-h interval when angiotensin II (AII) (10(-6) M, 3 ng/g) is injected post-training. By contrast, no amnestic effect of AII was found even though high doses were administered. The facilitatory effect of AII is suppressed by saralasin (10(-7) M, 0.3 ng/g), a specific angiotensin II receptor antagonist. Results are considered as suggesting that angiotensin on memory processes might have emerged early in evolution.

摘要

头顶上方移动的阴影作为一种危险刺激，会引发颗粒招潮蟹的逃避反应，这种反应在15次试验后会出现习惯化，且能持续很长时间。十次试验的较短训练未能诱导长期习惯化；然而，训练后注射血管紧张素II（AII）（10⁻⁶ M，3 ng/g），24小时后习惯化反应能良好保持。相比之下，即使给予高剂量，也未发现AII有遗忘作用。AII的促进作用被特异性血管紧张素II受体拮抗剂沙拉新（10⁻⁷ M，0.3 ng/g）抑制。研究结果表明，血管紧张素对记忆过程的作用可能在进化早期就已出现。