Schottler Nadine Iman, Sutcliffe Alastair G
Population, Policy and Practice Unit, University College London, London, UK.
Institute of Child Health, University College London, London, UK
Arch Dis Child. 2024 Dec 13;110(1):12-17. doi: 10.1136/archdischild-2023-326023.
More than 10 million children have been born with assisted reproductive technology (ART) as we begin to enter the third generation of individuals conceived by ART. Here we summarise key messages from an enlarging body of literature regarding their health. Earlier research had pointed towards increases in perinatal, neonatal and neurological risks, such as preterm birth, low birth weight, congenital malformations and cerebral palsy. Many of these risks have continued to persist in most recent work but have shown reduction. Newer research proposes long-term cardiometabolic and endocrine concerns. Fortunately, most reports conclude there is little or no risk of increased childhood malignancy or abnormal neurodevelopment. Moving forward, new research may benefit from changes in comparator groups and a better understanding of infertility per se in ART, and the confounding role it probably plays in many of the known risk associations, to reliably scan the horizon for health threats for individuals born after ART.
随着我们开始进入第三代通过辅助生殖技术（ART）受孕出生的个体，已有超过1000万儿童通过ART出生。在此，我们总结了大量关于他们健康状况的文献中的关键信息。早期研究指出围产期、新生儿期和神经方面的风险增加，如早产、低出生体重、先天性畸形和脑瘫。在最近的研究中，许多这些风险仍然存在，但已有所降低。新的研究提出了长期的心脏代谢和内分泌问题。幸运的是，大多数报告得出结论，儿童患恶性肿瘤增加或神经发育异常的风险很小或没有。展望未来，新的研究可能会受益于比较组的变化以及对ART中不孕症本身的更好理解，以及它可能在许多已知风险关联中所起的混杂作用，从而可靠地审视ART后出生个体面临的健康威胁。
