[Effect of soluble streptocide on the function of type III glucocorticoid receptors in rat liver cytosol].

The effects of soluble streptocidum on the function of Type III glucocorticoid receptors in the hepatic cytosol were examined in Wistar rats weighing 180-200 g. The Scatchard Lainuiver-Berk established that soluble streptocidum resulted in a concentration-dependent increase in the number of Type III glucocorticoid receptor binding sites. At the same time the measured constant of interaction of labelled corticosterone with Type III glucocorticoid receptors and the dissociation constant of these complexes slightly changed with streptocidum. Soluble streptocidum-induced stimulation of the function of Type III glucocorticoid receptors was effected via the non-competitive type. Whether Type III glucocorticoid receptors directly involve in the mechanism of the antiphlogogenic effect of soluble streptocidum in aseptic inflammation is discussed in the paper.