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免疫球蛋白/增强子结合蛋白（C/EBPγ）是C/EBP家族转录激活因子的一种反式显性负性抑制剂。

Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators.

作者信息

Cooper C, Henderson A, Artandi S, Avitahl N, Calame K

机构信息

Department of Microbiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

出版信息

Nucleic Acids Res. 1995 Nov 11;23(21):4371-7. doi: 10.1093/nar/23.21.4371.

DOI:10.1093/nar/23.21.4371
PMID:7501458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC307392/
Abstract

Analysis of cDNA and genomic clones shows that the murine Ig/EBP (C/EBP gamma) gene encodes a small protein with a predicted molecular weight of 16.4 kDa which contains C/EBP family basic and leucine zipper domains but lacks the transcriptional activation domains present in C/EBP (C/EBP alpha) and NF-IL6 (C/EBP beta). In transfection assays Ig/EBP is neither an activator nor a repressor of transcription; however, Ig/EBP inhibits the transcriptional ability of NF-IL6 (C/EBP beta) and C/EBP (C/EBP alpha), acting as a transdominant negative regulator. Thus Ig/EBP resembles LIP, another negative regulator of the C/EBP family, in both structure and transcriptional activity. Of the three known C/EBP family inhibitors, Ig/EBP, LIP and CHOP-10, only Ig/EBP is ubiquitously expressed. Therefore, Ig/EBP may act as a general buffer for C/EBP activators in many cell types.

摘要

对cDNA和基因组克隆的分析表明，小鼠Ig/EBP（C/EBPγ）基因编码一种预测分子量为16.4 kDa的小蛋白，该蛋白含有C/EBP家族的碱性和亮氨酸拉链结构域，但缺乏C/EBP（C/EBPα）和NF-IL6（C/EBPβ）中存在的转录激活结构域。在转染实验中，Ig/EBP既不是转录激活剂也不是转录抑制剂；然而，Ig/EBP抑制NF-IL6（C/EBPβ）和C/EBP（C/EBPα）的转录能力，作为一种反式显性负调节因子发挥作用。因此，Ig/EBP在结构和转录活性上类似于C/EBP家族另一负调节因子LIP。在三种已知的C/EBP家族抑制剂Ig/EBP、LIP和CHOP-10中，只有Ig/EBP在各处均有表达。因此，Ig/EBP可能在许多细胞类型中作为C/EBP激活剂的一种通用缓冲剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca37/307392/6aeaf590ebe1/nar00021-0157-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca37/307392/61315078ff9e/nar00021-0154-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca37/307392/6aeaf590ebe1/nar00021-0157-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca37/307392/61315078ff9e/nar00021-0154-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca37/307392/6aeaf590ebe1/nar00021-0157-a.jpg

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