Robison J M, Wilkie D J, Campbell B
School of Nursing, Lewis-Clark State College, Lewiston, Idaho, USA.
Nurs Clin North Am. 1995 Dec;30(4):725-43.
Clinical reports rave about the efficacy of sublingual morphine, but most research data suggest that sublingual morphine lacks the necessary physical characteristics to be absorbed through sublingual tissues. This article clarifies these assertions by reviewing the clinical literature that supports sublingual administration, the theories relevant to sublingual morphine administration, and the pharmacokinetic research that supports or negates the benefit of this route. Recommendations for clinical nursing practice are provided to guide decision-making in care of patients with cancer pain.
临床报告对舌下含服吗啡的疗效赞不绝口，但大多数研究数据表明，舌下含服吗啡缺乏通过舌下组织吸收所需的物理特性。本文通过回顾支持舌下给药的临床文献、与舌下含服吗啡给药相关的理论以及支持或否定该给药途径益处的药代动力学研究，对这些观点进行了阐释。文中还给出了临床护理实践建议，以指导癌症疼痛患者护理中的决策制定。
