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体外培养的细粒棘球绦虫原头节与阿苯达唑及阿苯达唑亚砜孵育后的抗微管蛋白免疫组织化学研究

Anti-tubulin immunohistochemistry study of Echinococcus granulosus protoscolices incubated with albendazole and albendazole sulphoxide in vitro.

作者信息

Pérez-Serrano J, Denegri G, Casado N, Bodega G, Rodríguez-Caabeiro F

机构信息

Laboratory of Parasitology, Faculty of Pharmacy, University of Alcalá de Henares, Madrid, Spain.

出版信息

Parasitol Res. 1995;81(5):438-40. doi: 10.1007/BF00931507.

DOI:10.1007/BF00931507
PMID:7501645
Abstract

Tubulin content was immunohistochemically studied in Echinococcus granulosus protoscolices incubated with albendazole and albendazole sulphoxide alone or in combination. Tubulin immunoreactivity was very patent in the control protoscolices and was mainly located in the sucker region and the invagination channel of protoscolices. Treated protoscolices always showed less immunoreactivity than did control protoscolices. We concluded that albendazole and its metabolite albendazole sulphoxide produce tubulin alterations in E. granulosus protoscolices.

摘要

采用免疫组织化学方法研究了单独或联合使用阿苯达唑和阿苯达唑亚砜孵育细粒棘球绦虫原头节时微管蛋白的含量。微管蛋白免疫反应性在对照原头节中非常明显，主要位于原头节的吸盘区域和内陷通道。处理后的原头节免疫反应性总是比对照原头节低。我们得出结论，阿苯达唑及其代谢产物阿苯达唑亚砜会导致细粒棘球绦虫原头节微管蛋白发生改变。

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本文引用的文献

1
The effects of albendazole and albendazole sulphoxide combination-therapy on Echinococcus granulosus in vitro.阿苯达唑与阿苯达唑亚砜联合治疗对细粒棘球绦虫的体外作用。
Int J Parasitol. 1994 Apr;24(2):219-24. doi: 10.1016/0020-7519(94)90029-9.
2
The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.免疫组织化学的未标记抗体酶法：可溶性抗原-抗体复合物（辣根过氧化物酶-抗辣根过氧化物酶）的制备、性质及其在螺旋体鉴定中的应用
J Histochem Cytochem. 1970 May;18(5):315-33. doi: 10.1177/18.5.315.
3
In vitro survival of Echinococcus granulosus protoscolices in several media, at +4 degrees C and +37 degrees C.
Z Parasitenkd. 1986;72(2):273-8. doi: 10.1007/BF00931155.
4
Effect of albendazole sulphoxide on viability of hydatid protoscoleces in vitro.阿苯达唑亚砜对体外棘球蚴原头节活力的影响。
Trans R Soc Trop Med Hyg. 1986;80(5):815-7. doi: 10.1016/0035-9203(86)90392-5.
5
A comparison of the effects of albendazole, its sulphone metabolite, and mebendazole on the viability of protoscoleces of Echinococcus granulosus in an in vitro culture system.在体外培养系统中比较阿苯达唑、其砜代谢物和甲苯达唑对细粒棘球绦虫原头节活力的影响。
Trans R Soc Trop Med Hyg. 1987;81(5):804-6. doi: 10.1016/0035-9203(87)90038-1.
6
The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles.
Int J Parasitol. 1988 Nov;18(7):885-936. doi: 10.1016/0020-7519(88)90175-0.
7
In vitro effects of levamisole and ivermectin against Echinococcus granulosus protoscoleces.左旋咪唑和伊维菌素对细粒棘球绦虫原头蚴的体外作用。
Int J Parasitol. 1989 Dec;19(8):945-7. doi: 10.1016/0020-7519(89)90125-2.
8
Biochemical effects of luxabendazole on Trichinella spiralis.鲁苯达唑对旋毛虫的生化作用。
Parasitol Res. 1990;76(6):518-20. doi: 10.1007/BF00931057.
9
A possible biochemical mode of action for benzimidazole anthelmintics.
Int J Parasitol. 1991 Feb;21(1):99-104. doi: 10.1016/0020-7519(91)90125-q.
10
Preliminary characterization and interaction of tubulin from Trichinella spiralis larvae with benzimidazole derivatives.旋毛虫幼虫微管蛋白与苯并咪唑衍生物的初步特性及相互作用
Vet Parasitol. 1991 Jul;39(1-2):89-99. doi: 10.1016/0304-4017(91)90065-4.