Borlongan C V, Martinez R, Shytle R D, Freeman T B, Cahill D W, Sanberg P R
Department of Surgery, University of South Florida College of Medicine, Tampa 33612, USA.
Pharmacol Biochem Behav. 1995 Sep;52(1):225-9. doi: 10.1016/0091-3057(95)00108-9.
Cerebral infarct (stroke) causes striatal damage with subsequent deterioration of sensorimotor and cognitive functions that may be mediated by the dopamine receptor system. In the present study, transient, focal ischemia was induced in Sprague-Dawley rats by middle cerebral artery occlusion. Ischemic animals exhibited significantly less dopamine antagonist (haloperidol)-induced catalepsy and more dopamine agonist (amphetamine)-induced hyperactivity than sham-operated animals. Younger ischemic animals showed more profound behavioral alteration but also displayed greater recovery over time than older ischemic animals. Histologic data revealed a lateral striatal lesion in all ischemic animals. These results place the striatal dopaminergic system as a possible strategic venue for the treatment of cerebral ischemia. In addition, aging is found to be a risk factor for stroke as noted in humans.
脑梗死（中风）会导致纹状体损伤，随后感觉运动和认知功能会恶化，这可能由多巴胺受体系统介导。在本研究中，通过大脑中动脉闭塞在Sprague-Dawley大鼠中诱导短暂性局灶性缺血。与假手术动物相比，缺血动物表现出明显更少的多巴胺拮抗剂（氟哌啶醇）诱导的僵住症和更多的多巴胺激动剂（苯丙胺）诱导的多动。较年轻的缺血动物表现出更深刻的行为改变，但随着时间的推移，与较年长的缺血动物相比，恢复程度也更大。组织学数据显示所有缺血动物均有外侧纹状体损伤。这些结果表明纹状体多巴胺能系统可能是治疗脑缺血的一个重要靶点。此外，正如在人类中所观察到的，衰老被发现是中风的一个危险因素。
