Brock J W, Hamdi A, Ross K, Payne S, Prasad C
Laboratory of Neurosciences, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Pharmacol Biochem Behav. 1995 Sep;52(1):43-8. doi: 10.1016/0091-3057(94)00411-b.
REM sleep deprivation (RSD) of rats results in facilitation of dopaminergic behavior and an increase in striatal D2 receptor density. To determine whether RSD results in changes in D2 receptor in other brain regions, receptor affinity (Kd) and density (Bmax) were measured in the anteromediofrontal (AM), cingulate (CN), and sulcal cortex (SL) in four groups of rats: 1), RSD96 group (RSD for 96 h; small pedestal/water tank method), 2) RSD24 group (large pedestals for 72 h then small pedestals for 24 h), 3) tank control group (TC; large pedestals for 96 h), and 4) cage control group. In separate groups, ambulation was recorded for 30 min following treatments. Group RSD96 showed an increase in activity compared to TC, and TC was increased compared to CC (p < 0.05 for all). In group RSD24, the AM showed an increase in Bmax and Kd (p < 0.05), but there were no effects by RSD96. In the CN, Bmax and Kd were decreased by RSD96 (p < 0.05) but not RSD24. In the SL, Bmax was increased by RSD96, but not RSD24, whereas Kd was increased in both RSD groups (p < 0.05).
大鼠快速眼动睡眠剥夺（RSD）会导致多巴胺能行为的促进以及纹状体D2受体密度的增加。为了确定RSD是否会导致其他脑区D2受体的变化，对四组大鼠的前额内侧（AM）、扣带回（CN）和沟回皮质（SL）中的受体亲和力（Kd）和密度（Bmax）进行了测量：1）RSD96组（96小时快速眼动睡眠剥夺；小平台/水槽法），2）RSD24组（大平台放置72小时，然后小平台放置24小时），3）水槽对照组（TC；大平台放置96小时），以及4）笼养对照组。在单独的几组实验中，处理后记录30分钟的活动情况。与TC组相比，RSD96组的活动增加，且与CC组相比，TC组活动增加（所有p值均<0.05）。在RSD24组中，AM区域的Bmax和Kd增加（p<0.05），但RSD96组无此影响。在CN区域，RSD96组的Bmax和Kd降低（p<0.05），但RSD24组无此影响。在SL区域，RSD96组的Bmax增加，但RSD24组无此影响，而两组RSD组的Kd均增加（p<0.05）。
