Brekke J S, Raine A, Thomson C
School of Social Work, University of Southern California, Los Angeles 90089-0411, USA.
Psychiatry Res. 1995 Aug 28;57(3):241-50. doi: 10.1016/0165-1781(95)02668-m.
This study examined the cross-sectional and prospective relationships between cognitive and psychophysiological variables and positive, negative, and disorganized symptoms in 40 outpatients with diagnoses of schizophrenia or schizoaffective disorder. The results indicated that disorganized symptoms were related to deficits in auditory and visuomotor attentional processing, increased skin conductance orienting response, and lower stress reactivity. Negative symptoms were related to reduced resting heart rate, increased stress reactivity, and deficits in visuomotor processing. Prospective findings indicated that both the cognitive and heart-rate variables might be trait-related aspects of the negative symptoms, while the skin conductance, but not the cognitive, variables might be trait-related aspects of the disorganized symptoms. Positive symptoms were not related to any of the cognitive or psychophysiological variables.
本研究调查了40名被诊断为精神分裂症或分裂情感性障碍的门诊患者的认知和心理生理变量与阳性、阴性和紊乱症状之间的横断面及前瞻性关系。结果表明，紊乱症状与听觉和视觉运动注意加工缺陷、皮肤电定向反应增加以及较低的应激反应性有关。阴性症状与静息心率降低、应激反应性增加以及视觉运动加工缺陷有关。前瞻性研究结果表明，认知和心率变量可能是阴性症状的特质相关方面，而皮肤电变量（而非认知变量）可能是紊乱症状的特质相关方面。阳性症状与任何认知或心理生理变量均无关联。
