Tamburrini O, Sessa M, Della Sala M, Stanà C, De Caridi A, Carallo O F
Dipartimento di Medicina Sperimentale e Clinica, Universitá degli Studi, Reggio Calabria.
Radiol Med. 1995 Sep;90(3):187-93.
This study was aimed at assessing the MR patterns of transient osteoporosis of the hip and, consequently, the role of MRI in the diagnosis and follow-up of this condition. Even though this condition was originally observed in pregnant women, young or middle-aged men are most frequently affected. There is a spontaneous onset of pain, usually progressing over several weeks. The patients have no risk factors for osteonecrosis; they may have a history of minor trauma and there is a possible relationship to the third trimester of pregnancy. Laboratory values are negative. Pain may be severe enough to cause the patient to limp and to impair joint function. The possible causes of transient osteoporosis have been debated by many authors and include trauma, synovitis, neurovascular dysfunction and transient or reversible ischemia. Transient osteoporosis is a self-limiting disease which does not require surgical treatment. The differential diagnosis of transient osteoporosis of the hip is very important because this condition may simulate cancer, septic arthritis, osteomyelitis or avascular necrosis. We report the initial and follow-up features of transient osteoporosis of the hip on the MR images of 6 patients (M/F = 5/1; age: 37-49 years, mean: 41.8 years). The right side was involved in 3 patients, the left side in 2 patients. The patient with bilateral transient osteoporosis was a woman in the 3rd trimester of pregnancy. In all patients, MRI was performed with an 0.5 T MR unit. The MR changes in our 6 patients were rather uniform and included heterogeneous decrease in the signal intensity of the affected bone marrow on T1-weighted images and increased signal intensity on T2-weighted and STIR images, with no evidence of focal lesions. This pattern is known as the "bone marrow edema" (BME) pattern. All the patients received conservative treatment. The clinical symptoms and the MR abnormalities regressed completely within 6-10 months, with no late sequelae. To conclude, this follow-up MR study demonstrates the transient, reversible character of transient osteoporosis of the hip. Until the natural history of the BME pattern is better understood, we suggest a conservative management of this condition, especially in the patients with no risk factors for osteonecrosis. Radiographic and MR follow-up is recommended.
本研究旨在评估髋关节一过性骨质疏松的磁共振成像(MR)表现,进而探讨MRI在该疾病诊断及随访中的作用。尽管这种疾病最初在孕妇中被观察到,但最常受累的是年轻或中年男性。疼痛通常自发出现,且在数周内逐渐加重。患者无骨坏死的危险因素;他们可能有轻微外伤史,且可能与妊娠晚期有关。实验室检查结果为阴性。疼痛可能严重到导致患者跛行并损害关节功能。许多作者对一过性骨质疏松的可能病因进行了讨论,包括外伤、滑膜炎、神经血管功能障碍以及一过性或可逆性缺血。一过性骨质疏松是一种自限性疾病,无需手术治疗。髋关节一过性骨质疏松的鉴别诊断非常重要,因为这种疾病可能类似癌症、化脓性关节炎、骨髓炎或缺血性坏死。我们报告了6例(男/女 = 5/1;年龄:37 - 49岁,平均41.8岁)髋关节一过性骨质疏松患者的初始及随访MR图像特征。右侧受累3例,左侧受累2例。双侧一过性骨质疏松的患者为一名妊娠晚期女性。所有患者均使用0.5T MR设备进行检查。我们6例患者的MR表现较为一致,包括T1加权像上受累骨髓信号强度不均匀降低,T2加权像和短T1反转恢复(STIR)像上信号强度增加,且无局灶性病变迹象。这种表现被称为“骨髓水肿”(BME)模式。所有患者均接受了保守治疗。临床症状和MR异常在6 - 10个月内完全消退,无晚期后遗症。总之,这项随访MR研究证实了髋关节一过性骨质疏松具有一过性、可逆性的特点。在对BME模式的自然病程有更好的了解之前,我们建议对这种疾病采取保守治疗,尤其是对于无骨坏死危险因素的患者。建议进行X线和MR随访。