Delbaere A, Rodesch C, Englert Y
Unité de Fertilité, Hôpital Erasme, Bruxelles.
Rev Med Brux. 1995 Nov;16(5):354-60.
The ovarian hyperstimulation syndrome (OHSS) is the most important complication of the pharmacological ovulation induction. Exclusively postovulatory, it is clinically characterized by a massive ovarian enlargement associated with an acute third-space fluid shift responsible for the development of ascites, and sometimes pleural and/or pericardial effusion. While mild OHSS has no consequence, severe forms can be life-threatening because of associated hemodynamic troubles. The main risk factors are the polycystic ovarian syndrome and an explosive ovarian response to the stimulation characterized by high serum oestradiol levels and an increased number of follicles. Ultrasound and endocrine monitoring make prevention measures possible, mainly by either abandoning the stimulation cycle or, during in vitro fertilization, cryopreserving the embryos for subsequent replacement in another cycle. Treatment consists in correcting circulatory and electrolyte imbalance. Paracentesis is more and more systematically proposed in the severe forms.
卵巢过度刺激综合征（OHSS）是药物诱导排卵最重要的并发症。仅在排卵后发生，其临床特征为卵巢大量肿大，并伴有急性第三间隙液体转移，导致腹水形成，有时还会出现胸腔和/或心包积液。轻度OHSS并无影响，而严重形式可能因相关的血液动力学问题而危及生命。主要危险因素是多囊卵巢综合征以及卵巢对刺激产生的爆发性反应，其特征为血清雌二醇水平升高和卵泡数量增加。超声和内分泌监测使预防措施成为可能，主要方法是放弃刺激周期，或者在体外受精过程中冷冻胚胎，以便在另一个周期中进行后续移植。治疗包括纠正循环和电解质失衡。对于严重形式，越来越多地系统性建议进行腹腔穿刺术。
