Becker H
Klinik und Poliklinik für Allgemeinchirurgie, Georg-August-Universität Göttingen.
Praxis (Bern 1994). 1995 Nov 21;84(47):1371-2.
Surgery is the primary mode of therapy for colonic and rectal cancer. The principles of surgery are: laparotomy for staging, wide en bloc resection of the primary tumor and lymphadenectomy for staging as well as possible therapeutic benefit. Reasonable efforts should be made intraoperatively to prevent intraluminal and intraperitoneal spread. Resection of metastases can prolong survival in stage D patients confined to the liver. Dukes C colon cancer patients should receive multiagent chemotherapy. There is no well defined role for radiation therapy as adjuvant treatment in colon cancer. Local failure pattern and treatment strategies are different for cancer of the rectum. Surgery remains the mainstay of treatment for all lesions; other modalities are adjunctive. Lesions within 5 cm of the anal verge usually require abdominoperineal resection, while the other are treated with a low anterior resection. New techniques are emerging to preserve the anal sphincter and gastrointestinal continuity, and these are being tested to determine if adequate tumor control is obtained.
手术是结肠癌和直肠癌的主要治疗方式。手术原则为:通过剖腹手术进行分期,整块广泛切除原发肿瘤并进行淋巴结清扫以分期,同时尽可能获得治疗益处。术中应做出合理努力以防止腔内和腹腔内播散。对于局限于肝脏的D期患者,切除转移灶可延长生存期。Dukes C期结肠癌患者应接受多药化疗。在结肠癌中,放疗作为辅助治疗尚无明确作用。直肠癌的局部失败模式和治疗策略有所不同。手术仍然是所有病变的主要治疗手段;其他方式为辅助手段。距肛缘5厘米以内的病变通常需要腹会阴联合切除术,而其他病变则采用低位前切除术治疗。正在出现一些保留肛门括约肌和胃肠道连续性的新技术,目前正在对其进行测试以确定是否能实现充分的肿瘤控制。