产前孕酮II。其在子痫前期中毒治疗中的作用及其对后代智力的影响：重新评估。

Prenatal progesterone II. Its role in the treatment of pre-eclamptic toxaemia and its effect on the off-spring's intelligence: a reappraisal.

作者信息

Lynch A, Mychalkiw W

出版信息

Early Hum Dev. 1978 Dec;2(4):323-39. doi: 10.1016/0378-3782(78)90060-9.

Abstract

Dalton's results concerning the beneficial effect of progesterone supplementation in preventing pre-eclamptic toxaemia [16] and in enhancing intellectual potential [17,18] were reappraised. We could find no evidence in the data that progesterone supplementation was any better at preventing pre-eclamptic toxaemia than treating the disorder symptomatically. Nor could we find any convincing evidence that excess progesterone enhances development at 1 yr of age, academic attainment at 9--10 yr of age, or success in school leaving examinations and improves the chances of continuing further full-time education after leaving school.

摘要

重新评估了道尔顿关于补充孕酮在预防先兆子痫中毒[16]以及提高智力潜能[17,18]方面有益效果的研究结果。我们在数据中找不到证据表明补充孕酮在预防先兆子痫中毒方面比对症治疗该疾病更有效。我们也找不到任何令人信服的证据表明过量的孕酮能促进1岁时的发育、9至10岁时的学业成绩、离校考试的成功率，或者提高离校后继续接受全日制教育的机会。