Fujimoto J, Hori M, Ichigo S, Morishita S, Tamaya T
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Tumour Biol. 1996;17(1):48-57. doi: 10.1159/000217966.
The migration potential through a basement membrane in an endometrial cancer cell line, such as Ishikawa, HEC-1-A or HHUA cell, in terms of strength, was enhanced by estradiol, but not modified by progesterone, medroxyprogesterone acetate (MPA), danazol or tamoxifen alone, by which estradiol-enhanced migration potential was inhibited. The order of the level of estrogen receptor was Ishikawa > HEC-1-A > HHUA cells. Therefore, it is suggested that the invasiveness of endometrial cancer cells might be activated by estradiol via estrogen receptors, but inactivated by progesterone, MPA, danazol or tamoxifen as an antiestrogen action, and that endometrial cancer cells could become invasive in the estrogen-predominant milieu, and the antiestrogenic agents could protect it.
在子宫内膜癌细胞系（如石川细胞、HEC - 1 - A细胞或HHUA细胞）中，就强度而言，通过基底膜的迁移潜能会被雌二醇增强，但单独使用孕酮、醋酸甲羟孕酮（MPA）、达那唑或他莫昔芬则不会对其产生改变，而雌二醇增强的迁移潜能会被这些物质抑制。雌激素受体水平的顺序为石川细胞＞HEC - 1 - A细胞＞HHUA细胞。因此，提示子宫内膜癌细胞的侵袭性可能通过雌激素受体被雌二醇激活，但作为抗雌激素作用会被孕酮、MPA、达那唑或他莫昔芬灭活，并且子宫内膜癌细胞在以雌激素为主的环境中可能会具有侵袭性，而抗雌激素药物可以起到保护作用。
