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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Fujimoto J, Hori M, Ichigo S, Hirose R, Tamaya T

Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.

Gen Pharmacol. 1997 Feb;28(2):215-9. doi: 10.1016/s0306-3623(96)00188-7.

The levels of basic fibroblast growth factor (FGF) expression and secretion and its messenger ribonucleic acid (mRNA) expression in well-differentiated endometrial cancer (Ishikawa) cells were significantly increased by estradiol. 2. This increase was significantly inhibited by tamoxifen, progestins (progesterone, medroxyprogesterone acetate [MPA], and 17 alpha-hydroxyprogesterone), and to some extent danazol, but not by terahydrocortisol and hydrocortisone. 3. Estrogen might stimulate the basic FGF secretion of endometrial cancer cells, at least for neovascularization, and antiestrogenic compounds may inhibit the estrogen-induced event.

雌二醇可显著提高高分化子宫内膜癌（Ishikawa）细胞中碱性成纤维细胞生长因子（FGF）的表达、分泌水平及其信使核糖核酸（mRNA）的表达。2. 他莫昔芬、孕激素（孕酮、醋酸甲羟孕酮[MPA]和17α-羟孕酮）以及在一定程度上达那唑可显著抑制这种增加，但四氢皮质醇和氢化可的松则无此作用。3. 雌激素可能刺激子宫内膜癌细胞分泌碱性FGF，至少对于新血管形成而言是这样，而抗雌激素化合物可能抑制雌激素诱导的事件。

Fujimoto J, Hori M, Ichigo S, Hirose R, Tamaya T

Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.

Gen Pharmacol. 1997 Feb;28(2):215-9. doi: 10.1016/s0306-3623(96)00188-7.

The levels of basic fibroblast growth factor (FGF) expression and secretion and its messenger ribonucleic acid (mRNA) expression in well-differentiated endometrial cancer (Ishikawa) cells were significantly increased by estradiol. 2. This increase was significantly inhibited by tamoxifen, progestins (progesterone, medroxyprogesterone acetate [MPA], and 17 alpha-hydroxyprogesterone), and to some extent danazol, but not by terahydrocortisol and hydrocortisone. 3. Estrogen might stimulate the basic FGF secretion of endometrial cancer cells, at least for neovascularization, and antiestrogenic compounds may inhibit the estrogen-induced event.

雌二醇可显著提高高分化子宫内膜癌（Ishikawa）细胞中碱性成纤维细胞生长因子（FGF）的表达、分泌水平及其信使核糖核酸（mRNA）的表达。2. 他莫昔芬、孕激素（孕酮、醋酸甲羟孕酮[MPA]和17α-羟孕酮）以及在一定程度上达那唑可显著抑制这种增加，但四氢皮质醇和氢化可的松则无此作用。3. 雌激素可能刺激子宫内膜癌细胞分泌碱性FGF，至少对于新血管形成而言是这样，而抗雌激素化合物可能抑制雌激素诱导的事件。