Barrera-Rodríguez R, Peralta-Zaragoza O, Madrid-Marina V
Departamento de Bioquímica, Instituto Nacional de Enfermedades Respiratorias, México.
Salud Publica Mex. 1995 Jul-Aug;37(4):344-53.
The immune system is a tight network of different types of cells and molecules. The coordinated action of these elements mounts a precise immune response against tumor cells. However, these cells present several escape mechanisms, leading to tumor progression. This paper shows several cellular and molecular events involved in the regulation of the immune response against tumor cells. The interaction of several molecules such as MHC, TcR, adhesins, tumor antigens and cytokines are discussed, as well as the most recent knowledge about escape mechanisms and immunotherapy.
免疫系统是由不同类型的细胞和分子构成的紧密网络。这些元素的协同作用针对肿瘤细胞发起精确的免疫反应。然而，这些细胞存在多种逃逸机制，导致肿瘤进展。本文展示了参与调节针对肿瘤细胞免疫反应的若干细胞和分子事件。文中讨论了多种分子如主要组织相容性复合体（MHC）、T细胞受体（TcR）、黏附素、肿瘤抗原和细胞因子之间的相互作用，以及有关逃逸机制和免疫疗法的最新知识。
