Nishikawa H, Yasaki S, Yoshimoto T, Sakatani M, Itoh M, Masuno T, Namba M, Ogura T, Hirao F, Azuma I, Yamamura Y
Gan. 1978 Dec;69(6):819-24.
The effect of radiotherapy on peripheral blood lymphocytes (PBL) of lung cancer and the effect of BCG cell-wall skeleton (BCG-CWS) on recovery of impaired PBL were examined. A remarkable depression of the absolute number of E- or EAC-rosette cells and of the response of PBL to mitogens were observed immediately after radiotherapy, and these continued for several months. With BCG-CWS immunotherapy, the response of PBL to phytohemagglutinin recovered rapidly, compared with non-vaccinated patients. The response of PBL to pokeweed mitogen seemed to give similar results. These results suggested that BCG-CWS injection to the patient receiving radiotherapy was effective for recovery of T-cell response.
研究了放射疗法对肺癌患者外周血淋巴细胞（PBL）的影响以及卡介苗细胞壁骨架（BCG-CWS）对受损PBL恢复的影响。放疗后立即观察到E或EAC玫瑰花结细胞的绝对数量以及PBL对有丝分裂原的反应显著降低，且这种情况持续了数月。与未接种疫苗的患者相比，接受BCG-CWS免疫治疗的患者，其PBL对植物血凝素的反应迅速恢复。PBL对商陆有丝分裂原的反应似乎也得到了类似结果。这些结果表明，对接受放疗的患者注射BCG-CWS对T细胞反应的恢复有效。
