Yasumoto K, Manabe H, Ueno M, Ohta M, Ueda H
Gan. 1976 Dec;67(6):787-95.
Effect of BCG cell-wall skeleton (BCG-CWS) on the recovery of responsiveness of lymphocytes and the survival period was studied in patients with lung cancer. (a) Responsiveness of lymphocytes as demonstrated by proliferative response to phytohemagglutinin (PHA) or microcytotoxicity test with cultured cells of a bronchogenic carcinoma was depressed in the patients at later stages of cancer and it was restored by treatment with BCG-CWS in many of such patients. (b) Survival period of the patients at later stages such as III or IV was prolonged by treatment with BCG-CWS. Such an effect was detected even in the patients with carcinomatous pleuritis. (c) A close correlation was found between the reactivity such as PHA response or cytotoxicity and clinical course of the patients given BCG-CWS. Assay system with PHA response and microcytotoxicity test appears to be reliable in anticipating the prognosis and in following clinical course after the BCG-CWS treatment.
研究了卡介苗细胞壁骨架（BCG-CWS）对肺癌患者淋巴细胞反应性恢复及生存期的影响。（a）在癌症晚期患者中，淋巴细胞对植物血凝素（PHA）的增殖反应或对支气管源性癌细胞培养细胞的微量细胞毒性试验所显示的反应性降低，许多此类患者经BCG-CWS治疗后反应性得以恢复。（b）III期或IV期等晚期患者经BCG-CWS治疗后生存期延长。即使在癌性胸膜炎患者中也检测到了这种效果。（c）发现PHA反应或细胞毒性等反应性与接受BCG-CWS治疗患者的临床病程密切相关。PHA反应和微量细胞毒性试验的检测系统似乎在预测预后和跟踪BCG-CWS治疗后的临床病程方面是可靠的。
