Torres Valdivieso M J, López Pérez J, Melero C, Vivanco J L, Muley R, Vara J
Department of Pediatric Hematology-Oncology, Social Security Hospital 12 de Octubre, Madrid, Spain.
Med Pediatr Oncol. 1994;22(2):144-6. doi: 10.1002/mpo.2950220217.
We describe 2 cases of proximal tubular defects induced by the administration of ifosfamide at a dosage of 6 g/m2/course over 2 days in children with a diagnosis of malignant mesenchymal tumors. This adverse effect could be minimized dividing dosage of the drug. However at present it is not clear if divided doses are completely safe.
我们描述了2例诊断为恶性间叶肿瘤的儿童，在2天内以6 g/m²/疗程的剂量给予异环磷酰胺后出现近端肾小管缺陷的病例。这种不良反应可以通过将药物剂量分开来尽量减少。然而，目前尚不清楚分剂量是否完全安全。
