Rao S P, Miller S T, Cohen B J
Department of Pediatrics, SUNY Health Science Center, Brooklyn, NY 11203.
Med Pediatr Oncol. 1994;22(4):255-7. doi: 10.1002/mpo.2950220408.
Two children with rhabdomyosarcoma developed severe anemia following chemotherapy; anemia was more severe compared to that observed following earlier chemotherapy cycles. While one patient had a brisk reticulocytosis, the other had no demonstrable reticulocytes. Both patients had evidence of acute B19 parovirus infection and subsequently developed appropriate antibody response. A diagnosis of B19 parvovirus infection should be considered in any patient who develops persistent or severe anemia while on chemotherapy.
两名横纹肌肉瘤患儿在化疗后出现严重贫血；与早期化疗周期后观察到的情况相比，贫血更为严重。其中一名患者网织红细胞反应活跃，而另一名患者未检测到明显的网织红细胞。两名患者均有急性B19细小病毒感染的证据，随后产生了适当的抗体反应。对于任何在化疗期间出现持续性或严重贫血的患者，都应考虑诊断为B19细小病毒感染。
